Endocrine Abstracts

Increased plasma triglyceride (TG) concentration is an important risk factor for cardiovascular disease. Regular aerobic exercise is associated with lower plasma TG concentrations and lower cardiovascular risk. The cardioprotective effect of endurance-type physical activity is therefore likely, to some extent at least, linked to the hypotriglyceridemic effect of aerobic exercise. It has long been recognized that the TG-lowering effect of exercise manifests in response to a sin...

Objective: Hypothalamic obesity results in severe weight-gain and increased risk of cardiovascular and metabolic mortality. We aimed to assess the safety and efficacy of Tesomet (tesofensine plus metoprolol), and ongoing requirements in pituitary hormone replacement adjustments in adults with acquired hypothalamic obesity, a rare disease with no approved therapyResearch design, patients and methodsTwenty-one adults with hypothalami...

Background and objective: Hypothalamic obesity is characterized by rapid and severe weight-gain with increased risk of cardiovascular and metabolic disorders. Currently, there are no approved or effective pharmacological treatments and conventional weight management remain largely ineffective in hypothalamic obesity. This trial investigated safety and efficacy of Tesomet (0.5 mg tesofensine and 50 mg metoprolol) in hypopituitary patients with hypothalamic obesity.<p class=...